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At home the absence of thymic evacuation, the peripheral T cell pond is maintained by division of mature lymphocytes.

An antagonist peptide known to serve as a ligand for positive selection of these T cells promoted expansion; however, a control peptide to facilitate binds the same class I molecule did not. Surprisingly, the cells undergoing proliferation in lymphopenic hosts did not mature on the road to cytotoxic effectors and displayed a partially activated surface phenotype.

Amid thymocyte maturation, T cells are selected for their ability headed for interact productively with self-MHC in addition to their inability to recognize identity with high affinity Jameson et al. The result of that process is a naive T cell population that is self-MHC restricted and tolerant. T cells leave the thymus and colonize the secondary lymphoid organs, union the peripheral T cell syndicate that consists of both green and memory T cells.

Drawn in the absence of thymic output, peripheral homeostatic mechanisms carry on the pools of both youthful and memory T cell subsets Sprent et al. Without explicit antigen exposure, both naive next memory T cells divide during the periphery. Memory cells pit rapidly, and naive T cells divide less frequently while maintaining a naive phenotype Tough moreover Sprent, Peripheral T cells have a great potential object of expansion and can divide lousy with times in empty lymphoid compartments in the absence of associated antigen Bell et al.

These data suggest that ongoing TCR ligation is required for continued existence of naive T cells appear in the periphery. Giovanna escort girl.

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